Lean Body Mass and Body Surface Area Corrections for Intensity Bone Involvement (IBI) Index in Patients with Multiple Myeloma
DOI:
https://doi.org/10.29384/rbfm.2024.v18.19849001754Keywords:
18F-FDG PET/CT, multiple myeloma, lean body mass, body surface area, IBIAbstract
Intensity Bone Involvement (IBI) parameter is used to quantify the bone involvement in PET/CT images, making the analysis of these images more objective and reproducible. This study presents a proposal to apply the IBI mathematical correction for lean body mass and body surface area in 18F-FDG PET/CT images of patients diagnosed with multiple myeloma (MM) and to verify its respective relation with the visual analysis of these images. Methods: James and Janma models were used to calculate the lean body mass and DuBois model was used to calculate the body surface area. We compared standard IBI and its corrected values with clinical visual classification using the Kruskal-Wallis test with Dunn’s post-hoc test and the Cox proportional hazards regression analysis to test its association with the patients’ overall survival. Statistical significance was considered for p-values <0.05. Results: There was a positive relation between both IBI standard value and its corrected values with the visual analysis of the images. There were no statistically significant associations between the IBI values and patients’ overall survival. Conclusions: Corrected IBI showed the same performance as the standard IBI regarding the visual classification of images. However, IBI values (both standard and its corrections) were not associated with the patients’ survival (OS) in our study.
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Copyright (c) 2024 Giovanna Monteiro Bianchi J. Santos, Maria Emilia Seren Takahashi, Camila Mosci, Stephan P. M. Souza, Carmino Antonio de Souza , Irene G. H. Lorand-Metze, José Barreto Campello Carvalheira, Celso Darío Ramos
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