Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis

Authors

  • Lucas Diovani Lopes Narciso Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Phelipi Nunes Schuck Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Caroline Machado Dartora Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Cristina Sebastião Matushita Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS
  • Jefferson Becker Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS
  • Ana Maria Marques da Silva Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS http://orcid.org/0000-0002-5924-6852

DOI:

https://doi.org/10.29384/rbfm.2016.v10.n2.p39-43

Keywords:

[11C]-(R)-PK11195, PET, multiple sclerosis, semi-quantification, SUV

Abstract

PET brain images with [11C]-(R)-PK11195 are being widely used to visualize microglial activation in vivo in neurodegenerative diseases, such as multiple sclerosis (MS). The aim of this study is to investigate the uptake behavior in juxtacortical and periventricular regions of [11C]-(R)-PK11195 PET brain images reformatted in different time intervals by applying three methods, seeking method and time interval that significantly differentiate MS patients from healthy controls. Semiquantitative SUV and SUVR methods were applied to PET images from different time intervals acquired from 10 patients with MS and 5 healthy controls. The results show significant difference between groups for SUV (p = 0.01) in 40 to 60 min interval, and SUVR with white matter as reference (p < 0.01) in 10 to 60 min interval, measured in the juxtacortical and periventricular regions.

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Author Biographies

Lucas Diovani Lopes Narciso, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Bacharel em Física Médica, Licenciado em Física, Mestre em Engenharia Elétrica, Supervisor de Radioproteção em Medicina Nuclear pela CNEN (FM-0335), atuando em Medicina Nuclear e Radiodiagnóstico.

Phelipi Nunes Schuck, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Estudante de Física, linha de formação em Física Médica.

Caroline Machado Dartora, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Bacharel em Física Médica, Licenciado em Física, Mestre em Engenharia Elétrica.

Cristina Sebastião Matushita, Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS

Médica Nuclear, Responsável Técnica pelo Serviço de Medicina Nuclear do InsCer.

Jefferson Becker, Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS

Médico Neurologista, Professor da Faculdade de Medicina da PUCRS e Assessor para Assuntos Internacionais e Interinstitucionais do InsCer.

Ana Maria Marques da Silva, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Diretora e Professora da Faculdade de Física da PUCRS, Professora do Programa de Pós-Graduação em Engenharia Elétrica da PUCRS.

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Published

2016-12-31

How to Cite

Narciso, L. D. L., Schuck, P. N., Dartora, C. M., Matushita, C. S., Becker, J., & Marques da Silva, A. M. (2016). Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis. Brazilian Journal of Medical Physics, 10(2), 39–43. https://doi.org/10.29384/rbfm.2016.v10.n2.p39-43

Issue

Vol. 10 No. 2 (2016)

Section

Artigo Original

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