Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging

Authors

  • Icaro Agenor Ferreira de Oliveira Inbrain Lab / Department of Physics, FFCLRP / USP, Ribeirao Preto, Brazil http://orcid.org/0000-0002-7102-5569
  • Tiago M Guimarães Department of Neuroscience and Behavior, FMRP/ USP, Ribeirao Preto, Brazil
  • Roberto M Souza Department of Neuroscience and Behavior, FMRP/ USP, Ribeirao Preto, Brazil
  • Antonio C dos Santos Department of Medical Clinic, FMRP/ USP, Ribeirao Preto, Brazil
  • Joao Paulo M Sousa Department of Neuroscience and Behavior, FMRP/ USP, Ribeirao Preto, Brazil National Institute of Science and Technology – Translational Medicine (INCT-TM), CNPq, Brazil
  • Jaime E. C. Hallak Department of Neuroscience and Behavior, FMRP/ USP, Ribeirao Preto, Brazil National Institute of Science and Technology – Translational Medicine (INCT-TM), CNPq, Brazil
  • Renata F Leoni Inbrain Lab / Department of Physics, FFCLRP / USP, Ribeirao Preto, Brazil

DOI:

https://doi.org/10.29384/rbfm.2017.v11.n2.p30-33

Keywords:

magnetic resonance imaging, arterial spin labeling, cerebral blood flow, functional connectivity schizophrenia.

Abstract

Schizophrenia is a significant mental disorder that compromises structural and functional aspects of the brain, with an extreme effect on the patient’s thoughts, feelings, and behavior. Physiologically, in addition to functional and structural abnormalities, changes in neuronal activity are reported. Since the cerebral blood flow (CBF) is directly related to neuronal activity, the magnetic resonance imaging (MRI) technique called arterial spin labeling (ASL), which allows the quantification of CBF, is a useful tool in brain perfusional evaluation. In addition, ASL can be used to assess functional connectivity, which is efficient in investigating functional impairment between regions of the brain. Pseudo-continuous arterial spin labeling (pCASL) images were acquired from 28 schizophrenia patients in treatment and 28 age-matched healthy controls. Static CBF and connectivity patterns were assessed. Decreased CBF and functional connectivity were observed in regions that forms two resting brain networks, default mode (DMN) and salience (SN), for schizophrenia patients. Previous studies related the features of this pathology with altered resting CBF and functional disconnections. Therefore, using a noninvasive technique, we were able to find CBF deficits and altered functional organization of the brain in schizophrenia patients that are associated with the symptoms and characteristics of the disorder.

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Author Biography

Icaro Agenor Ferreira de Oliveira, Inbrain Lab / Department of Physics, FFCLRP / USP, Ribeirao Preto, Brazil

Atualmente, mestrando pela Universidade de São Paulo (USP) campus de Ribeirão Preto no programa Física Aplicada à Medicina e Biologia (FAMB), da Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Graduado em Física Médica pela FFCLRP/USP.

Áreas de atuação: Ressonância Magnética, arterial spin labeling, perfusão cerebral

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Published

2017-12-04

How to Cite

Oliveira, I. A. F. de, Guimarães, T. M., Souza, R. M., dos Santos, A. C., Sousa, J. P. M., Hallak, J. E. C., & Leoni, R. F. (2017). Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging. Brazilian Journal of Medical Physics, 11(2), 30–33. https://doi.org/10.29384/rbfm.2017.v11.n2.p30-33

Issue

Vol. 11 No. 2 (2017)

Section

Artigo Original

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