Português

Authors

DOI:

https://doi.org/10.29384/rbfm.2026.v20.19849001876

Keywords:

Português

Abstract

This study conducted a comparative analysis of image quality in SPECT imaging with the radionuclide ¹⁷⁷Lu, using three different collimators (LEGP, LEHR, and MEGP). Monte Carlo simulations with the SIMIND code, combined with image reconstruction in the CASToR software, were employed to assess the impact of scattered radiation on quantitative parameters such as contrast, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). For each collimator, three energy windows were evaluated: a 20% window centered at 113 keV, a second centered at 208 keV, and a combined window including both peaks. Results indicated that the high-resolution LEHR collimator was the most effective at preserving contrast and contour definition. The energy window centered at 208 keV proved most advantageous, offering the best balance between sensitivity and image quality, with the highest contrast and CNR values recorded. The findings emphasize the critical importance of selecting the appropriate collimator and energy window to achieve accurate ¹⁷⁷Lu imaging. However, additional studies incorporating scatter and attenuation correction methods, as well as experimental validation of the simulation results, are recommended.

Downloads

Download data is not yet available.

References

1. Dash A, Pillai MR, Knapp FF Jr. Production of (177)Lu for targeted radionuclide therapy: available options. Nucl Med Mol Imaging. 2015 Jun;49(2):85-107. doi:10.1007/s13139-014-0315-z.

2. Niu T, Fan M, Lin B, Gao F, Tan B, Du X. Current clinical application of lutetium 177 in solid tumors: review. Exp Ther Med. 2024;27(225). doi:10.3892/etm.2024.12514.

3. Garkavij M, Nickel M, Sjogreen Gleisner K, Ljungberg M, Ohlsson T, Wingårdh K, et al. 177Lu [DOTA0,Tyr3]octreotate therapy in patients with disseminated neuroendocrine tumors: analysis of dosimetry with impact on future therapeutic strategy. Cancer. 2010;116(4):1084–1092.

4. Ljungberg M, Celler A, Konijnenberg MW, Eckerman KF, Dewaraja YK, Sjogreen Gleisner K, et al. MIRD pamphlet no. 26: joint EANM/MIRD guidelines for quantitative 177Lu SPECT applied for dosimetry of radiopharmaceutical therapy. J Nucl Med. 2016;57(1):151–162.

5. Sekikawa Y, Funada K, Akamatsu G, et al. Monte Carlo simulation of the acquisition conditions for 177Lu molecular imaging of hepatic tumors. Ann Nucl Med. 2021;35(8):917–926.

6. Ramonaheng K, van Staden JA, du Raan H. Validation of a Monte Carlo modelled gamma camera for lutetium 177 imaging. Appl Radiat Isot. 2020;166:109385.

7. de Nijs R, Lagerburg V, Klausen TL, Holm S. Improving quantitative dosimetry in 177Lu DOTATATE SPECT by energy window based scatter corrections. Nucl Med Commun. 2014;35(5):522–533. https://doi.org/10.1097/MNM.0000000000000079.

8. Beauregard JM, Hofman MS, Pereira JM, Eu P, Hicks RJ. Quantitative 177Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system. Cancer Imaging. 2011;11(1):56–66.

9. D’Arienzo M, Cazzato M, Cozzella ML, Cox M, D’Andrea M, Fazio A, et al. Gamma camera calibration and validation for quantitative SPECT imaging with 177Lu. Appl Radiat Isot. 2016;112:156–164. https://doi.org/10.1016/j.apradiso.2016.03.007.

10. Shcherbinin S, Piwowarska Bilska H, Celler A, Birkenfeld B. Quantitative SPECT/CT reconstruction for 177Lu and 177Lu/90Y targeted radionuclide therapies. Phys Med Biol. 2012;57(18):5733–5747.

11. Ljungberg M, Sjogreen Gleisner K. The accuracy of absorbed dose estimates in tumours determined by quantitative SPECT: a Monte Carlo study. Acta Oncol. 2011;50:981–989.

12. Asmi H, Bentayeb F, Bouzekraoui Y, Bonutti F, Douama S. Energy window and collimator optimization in lutetium 177 single photon emission computed tomography imaging using Monte Carlo simulation. Indian J Nucl Med. 2019;35(1):36–39.

13. Ljungberg M. The SIMIND Monte Carlo Program. In: Monte Carlo Techniques in Radiation Therapy. Boca Raton: CRC Press; 2012. p. 111–128.

14. Merlin T, Stute S, Benoit D, Bert J, Carlier T, Comtat C, et al. CASToR: a generic data organization and processing code framework for multi modal and multi dimensional tomographic reconstruction. Phys Med Biol. 2018;63(18):185005.

15. Rasband WS. ImageJ [software on the Internet]. Bethesda, MD: U.S. National Institutes of Health; 1997 2018 [cited 2025 Apr 22]. Available from: https://imagej.net/ij/.

16. Cherry SR, Sorenson JA, Phelps ME. Physics in nuclear

medicine. 4th ed. Philadelphia: Elsevier/Saunders; 2012.

17. Huizing D.M.V., Sinaasappel M, Dekker MC, Stokkel MPM, de Wit van der Veen BJ. 177Lutetium SPECT/CT: evaluation of collimator, photopeak and scatter correction. J Appl Clin Med Phys. 2020;21:272–277

Published

2026-05-07

How to Cite

dos Santos Garcia, F. K., Português, P., Português, P., & Português, P. (2026). Português. Brazilian Journal of Medical Physics, 20, 876. https://doi.org/10.29384/rbfm.2026.v20.19849001876

Issue

Section

Artigo Original

Similar Articles

<< < 2 3 4 5 6 7 8 9 10 11 > >> 

You may also start an advanced similarity search for this article.