Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis

Autores

  • Lucas Diovani Lopes Narciso Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Phelipi Nunes Schuck Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Caroline Machado Dartora Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS
  • Cristina Sebastião Matushita Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS
  • Jefferson Becker Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS
  • Ana Maria Marques da Silva Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS http://orcid.org/0000-0002-5924-6852

DOI:

https://doi.org/10.29384/rbfm.2016.v10.n2.p39-43

Palavras-chave:

[11C]-(R)-PK11195, PET, multiple sclerosis, semi-quantification, SUV

Resumo

PET brain images with [11C]-(R)-PK11195 are being widely used to visualize microglial activation in vivo in neurodegenerative diseases, such as multiple sclerosis (MS). The aim of this study is to investigate the uptake behavior in juxtacortical and periventricular regions of [11C]-(R)-PK11195 PET brain images reformatted in different time intervals by applying three methods, seeking method and time interval that significantly differentiate MS patients from healthy controls. Semiquantitative SUV and SUVR methods were applied to PET images from different time intervals acquired from 10 patients with MS and 5 healthy controls. The results show significant difference between groups for SUV (p = 0.01) in 40 to 60 min interval, and SUVR with white matter as reference (p < 0.01) in 10 to 60 min interval, measured in the juxtacortical and periventricular regions.

Downloads

Não há dados estatísticos.

Biografia do Autor

Lucas Diovani Lopes Narciso, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Bacharel em Física Médica, Licenciado em Física, Mestre em Engenharia Elétrica, Supervisor de Radioproteção em Medicina Nuclear pela CNEN (FM-0335), atuando em Medicina Nuclear e Radiodiagnóstico.

Phelipi Nunes Schuck, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Estudante de Física, linha de formação em Física Médica.

Caroline Machado Dartora, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Bacharel em Física Médica, Licenciado em Física, Mestre em Engenharia Elétrica.

Cristina Sebastião Matushita, Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS

Médica Nuclear, Responsável Técnica pelo Serviço de Medicina Nuclear do InsCer.

Jefferson Becker, Instituto do Cérebro do Rio Grande do Sul (InsCer)/PUCRS

Médico Neurologista, Professor da Faculdade de Medicina da PUCRS e Assessor para Assuntos Internacionais e Interinstitucionais do InsCer.

Ana Maria Marques da Silva, Núcleo de Pesquisa em Imagens Médicas/Faculdade de Física/PUCRS

Diretora e Professora da Faculdade de Física da PUCRS, Professora do Programa de Pós-Graduação em Engenharia Elétrica da PUCRS.

Referências

Banati RB, Newcombe J, Gunn RN, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain a J Neurol. 2000;123:2321-2337.

Chauveau F, Boutin H, Van Camp N, Dolle F, Tavitian B. Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging. 2008;35(12):2304-2319.

Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292-302.

Banati RB. Visualising microglial activation in vivo. Glia. 2002;40(2):206-217.

Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4(3 Pt 1):153-158.

Kropholler M a, Boellaard R, Schuitemaker A, et al. Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies. J Cereb blood flow Metab Off J Int Soc Cereb Blood Flow Metab. 2005;25(7):842-851.

Kropholler MA, Boellaard R, Schuitemaker A, Folkersma H, van Berckel BNM, Lammertsma AA. Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies. J Cereb blood flow Metab Off J Int Soc Cereb Blood Flow Metab. 2006;26:1431-1441.

Schuitemaker A, van Berckel BNM, Kropholler M a, et al. Evaluation of methods for generating parametric (R)-[11C]PK11195 binding images. J Cereb Blood Flow Metab. 2007;27(9):1603-1615.

Schuitemaker A, van Berckel BNM, Kropholler M a., et al. SPM analysis of parametric (R)-[11C]PK11195 binding images: Plasma input versus reference tissue parametric methods. Neuroimage. 2007;35:1473-1479.

Debruyne JC, Van Laere KJ, Versijpt J, et al. Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients. Acta Neurol Belg. 2002;102(3):127-135.

Debruyne JC, Versijpt J, Van Laere KJ, et al. Pet visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol. 2003;10(3):257-264.

Hammoud D a, Endres CJ, Chander AR, et al. Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS. J Neurovirol. 2005;11:346-355.

Kumar A, Muzik O, Shandal V, Chugani D, Chakraborty P, Chugani HT. Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET. J Neuroinflammation. 2012;9:232.

Anderson AN, Pavese N, Edison P, et al. A systematic comparison of kinetic modelling methods generating parametric maps for [(11)C]-(R)-PK11195. Neuroimage. 2007;36(1):28-37.

Versijpt J, Debruyne JC, Laere KJ Van, et al. Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler. 2005;11(2):127-134.

Politis M, Giannetti P, Su P, et al. Increased PK11195 PET binding in the cortex of patients with MS correlates with disability. Neurology. 2012;79(6):523-530.

Cagnin A, Gerhard A, Banati RB. In vivo imaging of neuroinflammation. Eur Neuropsychopharmacol. 2002;12:581-586.

Juntu J, Sijbers J, Dyck D Van, Gielen J. Bias field correction for mri images. Comput Recognit Syst. 2005;30:543-551. doi:10.1007/3-540-32390-2_64.

Jenkinson M, Beckmann CF, Behrens TEJ, Woolrich MW, Smith SM. FSL. Neuroimage. 2012;62:782-790.

Downloads

Publicado

2016-12-31

Como Citar

Narciso, L. D. L., Schuck, P. N., Dartora, C. M., Matushita, C. S., Becker, J., & Marques da Silva, A. M. (2016). Semiquantification Study of [11C]-(R)-PK11195 PET Brain Images in Multiple Sclerosis. Revista Brasileira De Física Médica, 10(2), 39–43. https://doi.org/10.29384/rbfm.2016.v10.n2.p39-43

Edição

Seção

Artigo Original

Artigos mais lidos pelo mesmo(s) autor(es)

1 2 3 > >>